EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.16.1.8 | 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine |
- |
Homo sapiens |
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ |
- |
? |
| 1.16.1.8 | 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ |
- |
Homo sapiens |
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine |
- |
? |
| 1.16.1.8 | 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ |
the enzyme catalyzes the oxidation of NADPH and shuttles electrons via its FAD and FMN cofactors to inactive MScob(II)alamin |
Homo sapiens |
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine |
- |
? |
| 1.16.1.8 | 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ |
the enzyme transfers reducing equivalents from NADPH via an FAD and FMN cofactor to a redox partner protein. hydride transfer from NADPH to FAD requires displacement of a conserved tryptophan that lies coplanar to the FAD isoalloxazine ring |
Homo sapiens |
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine |
- |
? |
| 1.16.1.8 | more |
difference in the relative efficiency of the very common polymorphic variant of the enzyme, I22M, suggests a molecular mechanism underlying the risk associated wiith the M22 allele for mild hyperhomocysteinemia |
Homo sapiens |
? |
- |
? |
| 1.16.1.8 | more |
biological implications of an attenuated mechanism of MS reactivation by MSR on methionine and folate metabolism, overview |
Homo sapiens |
? |
- |
? |
| 1.16.1.8 | more |
the enzyme catalyzes also the inhibition of reduction of cytochrome c3+ |
Homo sapiens |
? |
- |
? |
| 1.16.1.8 | more |
the enzyme catalyzes the reduction of cytochrome c3+ with NADPH and NADH |
Homo sapiens |
? |
- |
? |
| 1.16.1.8 | more |
fully reduced enzyme reaction with excess of cytochrome c, kinetics, overview. The NADPH-bound, fully reduced MSR completes most of its first turnover within the mixing dead time of the instrument, leaving only approximately 28% of the first turnover observable |
Homo sapiens |
? |
- |
? |
| 1.16.1.8 | [methionine synthase]-cob(II)alamin + NADH + S-adenosyl-L-methionine |
- |
Homo sapiens |
[methionine synthase]methylcob(I)alamin + S-adenosylhomocysteine + NAD+ |
- |
? |
