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Information on EC 1.16.1.8 - [methionine synthase] reductase

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EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.8 [methionine synthase] reductase
IUBMB Comments
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated [Co(II)] form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
methionine synthase reductase, nadph-dependent diflavin oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
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PATHWAY SOURCE
PATHWAYS
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