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Results 1 - 10 of 89 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
leukotriene A4 + H2O
-
(5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid + leukotriene B4 + (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
when large amounts of enzyme are incubated with leukotriene A4: 72% (5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid, 18% leukotriene B4 and 10% (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic acid
?
leukotriene A4 + H2O
-
leukotriene B4 + 5(S),12R-dihydroxy-6,10-trans-8,14-ciseicosatetraenoic acid
product ratio 9:1
?
leukotriene A4 + H2O
model for the binding of leukotriene A4 to the active site
leukotriene B4
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30%
?
leukotriene A4 + H2O
model for the binding of leukotriene A4 to the active site
leukotriene B4
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30%
?
leukotriene A4 + H2O
model for the binding of leukotriene A4 to the active site
leukotriene B4
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30%
?
leukotriene A4 + H2O
model for the binding of leukotriene A4 to the active site
leukotriene B4
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30%
?
leukotriene A4 + H2O
-
leukotriene B4
LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions
?
leukotriene A4 + H2O
LTA4
leukotriene B4
LTB4
?
leukotriene A4 + H2O
-
leukotriene B4
i.e. LTB4, a powerful proinflammatory agent
?
leukotriene A4 + H2O
-
leukotriene B4
i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid
?
Results 1 - 10 of 89 > >>