EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.208 | S-adenosyl-L-methionine + uridine2479 in 23S rRNA |
- |
Streptomyces viridochromogenes |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA |
- |
? |
2.1.1.208 | S-adenosyl-L-methionine + uridine2479 in 23S rRNA |
AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of uridine2479 of the 23S ribosomal RNA in Gram-positive bacteria and thus mediates resistance to the oligosaccharide antibiotic avilamycin |
Streptomyces viridochromogenes |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA |
- |
? |
2.1.1.208 | S-adenosyl-L-methionine + uridine2479 in 23S rRNA |
AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89 |
Streptomyces viridochromogenes |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA |
- |
? |
2.1.1.208 | S-adenosyl-L-methionine + uridine2479 in 23S rRNA |
AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA |
Streptomyces viridochromogenes |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA |
- |
? |