EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
  1.8.4.13 | L-methionine (S)-sulfoxide + NADPH + H+ |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
L-methionine + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine sulfoxide enkephalin + NADPH |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
L-methionine enkephalin + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine-(S)-S-oxide + thioredoxin |
- |
Escherichia coli |
L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.13 | more |
the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions |
Escherichia coli |
? |
- |
? |
| 1.8.4.13 | more |
substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation |
Escherichia coli |
? |
- |
? |
| 1.8.4.13 | more |
no activity with peptide-L-methionine-(S)-S-oxide |
Escherichia coli |
? |
- |
? |
| 1.8.4.13 | N-acetyl-L-methionine (S)-sulfoxide + thioredoxin |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
N-acetyl-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.13 | sulindac + NADPH |
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity |
? |
| 1.8.4.13 | sulindac + NADPH |
activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine (S)-S-oxide + NADPH |
- |
Escherichia coli B |
L-methionine + NADP+ + H2O |
- |
? |
