EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  1.8.4.13 | L-methionine (S)-S-oxide + NADPH |
- |
Escherichia coli B |
L-methionine + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine-(S)-S-oxide + thioredoxin |
- |
Escherichia coli |
L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.13 | sulindac + NADPH |
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity |
? |
| 1.8.4.13 | sulindac + NADPH |
activity with membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
sulindac sulfide + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine (S)-S-oxide + reduced DTT |
highest activity at 10 mM |
Escherichia coli B |
L-methionine + oxidized DTT + H2O |
- |
? |
| 1.8.4.13 | L-methionine (S)-sulfoxide + NADPH + H+ |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
L-methionine + NADP+ + H2O |
- |
? |
| 1.8.4.13 | L-methionine sulfoxide enkephalin + NADPH |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
L-methionine enkephalin + NADP+ + H2O |
- |
? |
| 1.8.4.13 | N-acetyl-L-methionine (S)-sulfoxide + thioredoxin |
membrane-bound enzyme form Mem-R,S-Msr |
Escherichia coli |
N-acetyl-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.13 | more |
methionine sulfoxide reduction pathway, overview |
Escherichia coli B |
? |
- |
? |
| 1.8.4.13 | more |
no activity with peptide-L-methionine-(S)-S-oxide |
Escherichia coli |
? |
- |
? |
