EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.315 | 11-cis-retinol + NAD+ |
- |
Bos taurus |
11-cis-retinal + NADH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
Bos taurus |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
- |
? |
1.1.1.315 | 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ |
- |
Bos taurus |
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+ |
- |
? |
1.1.1.315 | all-trans-retinol + NAD+ |
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 |
Bos taurus |
all-trans-retinal + NADH + H+ |
- |
r |
1.1.1.315 | all-trans-retinol + NADP+ |
the addition of NADP+ results in more efficient oxidation of all-trans retinol into all-trans retinal, when compared with the addition of NAD+, suggesting that RDH10 prefers NADP as the cofactor. At assay conditions (pH 5.5 and pH 7.6), and NADH or NADPH is used as the cofactor, only a low level of all-trans retinol is generated by RDH10 |
Bos taurus |
all-trans-retinal + NADPH + H+ |
- |
r |
1.1.1.315 | more |
RDH10 does not oxidize 11-cis retinol, 9-cis retinol, or 13-cis retinol into the respective retinal (pH 7.6, in the presence of NAD or NADP+), indicating the substrate specificity of RDH10 |
Bos taurus |
? |
- |
? |
1.1.1.315 | more |
cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR |
Bos taurus |
? |
- |
? |
1.1.1.315 | 11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+ |
in presence of excess NADH, wild-type catalyzes the reduction of 11-cis-retinal |
Homo sapiens |
11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ |
- |
r |
1.1.1.315 | 11-cis-retinol + NAD+ |
- |
Homo sapiens |
11-cis-retinal + NADH |
- |
? |
1.1.1.315 | 11-cis-retinol + NAD+ |
Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism. Substrate specificity and expression locus of Rdh5 suggest that it could serve as both an 11-cis-retinol dehydrogenase in the RPE and a 9-cis-retinol dehydrogenase and/or an androgen dehydrogenase outside of the retinal pigment epithelium |
Homo sapiens |
11-cis-retinal + NADH |
- |
? |