EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    5.1.3.14 | UDP-N-acetyl-D-glucosamine |
enzyme of biosynthesis of N-acetylneuraminic acid |
Rattus norvegicus |
? |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine |
initial enzyme responsible for the biosynthesis of CMP-N-acetylneuraminic acid |
Rattus norvegicus |
? |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine |
possible role in the biogenesis of N-acetylmannosamine-containing macromolecules |
Rattus norvegicus |
? |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine |
- |
Rattus norvegicus Wistar |
? |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine + H2O |
- |
Mus musculus |
UDP + N-acetylmannosamine |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine + H2O |
- |
Homo sapiens |
UDP + N-acetylmannosamine |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine + H2O |
- |
Rattus norvegicus |
UDP + N-acetylmannosamine |
- |
? |
| 5.1.3.14 | UDP-N-acetyl-D-glucosamine + H2O |
epimerase active site amino acid residues D21, G111, H132, G136 and D144 are required for stabilization of the active site structure, residues R19, S301 and E307 are involved in binding of the UDP portion of the substrate. Amino acid residues K24, P27, M29, D112, E134, D143, D144, R147, S302 and R113 are located in vicinity of the active site, while residues G182 and D187 are part of the active site hinge region. The possible general catalyst is residue H220, and residues H45 and H132 are required for 2-epimerase activity |
Homo sapiens |
UDP + N-acetylmannosamine |
- |
? |
| 5.1.3.14 | UDP-N-acetylgalactosamine |
- |
Rattus norvegicus |
? |
- |
? |
| 5.1.3.14 | uridine 5'-diphospho-2-hydroxyacetamido-2-deoxy-alpha-D-mannopyranoside |
- |
Neisseria meningitidis serogroup A / serotype 4A |
? |
- |
? |
