EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
one of the key enzymes of the methylcitrate cycle. Deletion mutants do not grow on propionate as sole carbon and energy source and are severely inhibited during growth on alternative carbon sources, when propionate is present. The strongest inhibitory effect is observed, when glycerol is the main carbon source, followed by glucose and acetate. In addition, asexual conidiation is strongly impaired in the presence of propionate |
Aspergillus nidulans |
Pyruvate + succinate |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
a catalytic mechanism is proposed that involves an R-carboxy-carbanion intermediate/transition state, which is consistent with previous stereochemical experiments showing inversion of configuration at the C(3) of 2-methyl-isocitrate |
Escherichia coli |
Pyruvate + succinate |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
the enzyme is highly specific for (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate |
Aspergillus nidulans |
Pyruvate + succinate |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
- |
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 |
Pyruvate + succinate |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme synthesis is repressed by glucose |
Yarrowia lipolytica |
? |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme of propionate catabolism |
Neurospora crassa |
? |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme of propionate catabolism |
Aspergillus niger |
? |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme of propionate catabolism |
Diutina rugosa |
? |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme of propionate catabolism |
Wickerhamiella pararugosa |
? |
- |
? |
| 4.1.3.30 | (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate |
enzyme of propionate catabolism |
Rhizopus microsporus var. chinensis |
? |
- |
? |
