4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate - Mycolicibacterium smegmatis Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate - Yarrowia lipolytica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate - Mycobacterium tuberculosis Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate reverse reaction not detected Yarrowia lipolytica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate specific for threo-DS-2-methylisocitrate Yarrowia lipolytica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate no activity with 2R,3S-isocitrate Yarrowia lipolytica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate i.e. 2-methylisocitrate, , threo-DS-2-methylisocitrate Yarrowia lipolytica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate syn: methylisocitrate Salmonella enterica Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate syn: methylisocitrate Escherichia coli Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate syn: methylisocitrate, enzyme acts only on threo-diastereomer, but not on the erythro-diastereomer Aspergillus nidulans Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate one of the key enzymes of the methylcitrate cycle. Deletion mutants do not grow on propionate as sole carbon and energy source and are severely inhibited during growth on alternative carbon sources, when propionate is present. The strongest inhibitory effect is observed, when glycerol is the main carbon source, followed by glucose and acetate. In addition, asexual conidiation is strongly impaired in the presence of propionate Aspergillus nidulans Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate a catalytic mechanism is proposed that involves an R-carboxy-carbanion intermediate/transition state, which is consistent with previous stereochemical experiments showing inversion of configuration at the C(3) of 2-methyl-isocitrate Escherichia coli Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate the enzyme is highly specific for (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate Aspergillus nidulans Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate - Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 Pyruvate + succinate - ? 1883 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme synthesis is repressed by glucose Yarrowia lipolytica ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Neurospora crassa ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Aspergillus niger ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Diutina rugosa ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Wickerhamiella pararugosa ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Rhizopus microsporus var. chinensis ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Mucor rouxianus ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Ustilago utriculosa ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Ustilago crus-galli ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate key enzyme in propionate metabolism Yarrowia lipolytica ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate the enzyme may function to supply pyruvate, the end-product of the catabolism of the propionate residue, to various reactions Yarrowia lipolytica ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate regulatory enzyme of the methylcitric acid cycle Yarrowia lipolytica ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Rhizopus microsporus var. chinensis IAM 6003 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Neurospora crassa IFO 6067 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Mucor rouxianus IFO 5773 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Ustilago utriculosa F-B-5 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Diutina rugosa IFO 0750 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Wickerhamiella pararugosa IFO 0966 ? - ? 369437 4.1.3.30 (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate enzyme of propionate catabolism Ustilago crus-galli F-B-6 ? - ? 369437 4.1.3.30 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate - Pseudomonas aeruginosa succinate + pyruvate - ? 427237 4.1.3.30 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate - Mycobacterium tuberculosis succinate + pyruvate - ? 427237 4.1.3.30 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate - Trichoderma atroviride succinate + pyruvate - ? 427237 4.1.3.30 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate - Mycobacterium tuberculosis BCG succinate + pyruvate - ? 427237 4.1.3.30 (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate - Trichoderma atroviride IMI206040 succinate + pyruvate - ? 427237 4.1.3.30 2-methylisocitrate - Bacillus subtilis succinate + pyruvate - ? 444152 4.1.3.30 2-methylisocitrate the enzyme is involved in the methylcitric acid cycle Bacillus subtilis succinate + pyruvate - ? 444152 4.1.3.30 2-methylisocitrate - Bacillus subtilis 168 succinate + pyruvate - ? 444152 4.1.3.30 2-methylisocitrate the enzyme is involved in the methylcitric acid cycle Bacillus subtilis 168 succinate + pyruvate - ? 444152 4.1.3.30 2-methylisocitrate lactone - Fusarium graminearum succinate + pyruvate - ? 407873 4.1.3.30 2-methylisocitrate lactone - Fusarium graminearum Z03643 succinate + pyruvate - ? 407873 4.1.3.30 methylisocitrate - Aspergillus fumigatus succinate + pyruvate - ? 417300 4.1.3.30 methylisocitrate - Aspergillus fumigatus Af293 succinate + pyruvate - ? 417300 4.1.3.30 additional information no substrate: isocitrate Aspergillus nidulans ? - ? 89 4.1.3.30 additional information no substrate: isocitrate Salmonella enterica ? - ? 89 4.1.3.30 additional information enzyme in methylcitrate cycle Salmonella enterica subsp. enterica serovar Typhimurium ? - ? 89 4.1.3.30 additional information enzyme in methylcitrate cycle Saccharomyces cerevisiae ? - ? 89 4.1.3.30 additional information enzyme in methylcitrate cycle Aspergillus nidulans ? - ? 89 4.1.3.30 additional information enzyme in methylcitrate cycle Salmonella enterica ? - ? 89 4.1.3.30 additional information enzyme in methylcitrate cycle Escherichia coli ? - ? 89 4.1.3.30 additional information Mycobacterium tuberculosis isocitrate lyases are catalytically bifunctional isocitrate and methylisocitrate lyases, EC 4.1.3.1 and EC 4.1.3.30, required for growth on even and odd chain fatty acids Mycobacterium tuberculosis ? - ? 89