EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.6.1.55 | 8-oxo-dGTP + H2O |
- |
Homo sapiens |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
- |
Ciona intestinalis |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
- |
Arabidopsis thaliana |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
- |
Mycolicibacterium smegmatis |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
high activity |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
8-oxoguanine (8-oxo-7,8-dihydroguanine) is produced in nucleic acids as well as in nucleotide pools of cells, by reactive oxygen species normally formed during cellular metabolic processes. MutT protein of Escherichia coli specifically degrades 8-oxoGua-containing deoxyribo- and ribonucleoside triphosphates to corresponding nucleoside monophosphates, thereby preventing misincorporation of 8-oxoguanine into DNA and RNA, which would cause mutation and phenotypic suppression, respectively |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
| 3.6.1.55 | 8-oxo-dGTP + H2O |
the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA |
Escherichia coli |
8-oxo-dGMP + diphosphate |
- |
? |
