EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.22.51 | benzoyl-HR-4-methylcoumarin 7-amide + H2O |
less susceptible substrate |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | benzoyl-RR-4-methylcoumarin 7-amide + H2O |
less susceptible substrate |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | o-aminobenzoyl-KLRFSFQ-N-(2,4-dinitrophenyl)-ethylenediamine + H2O |
no hydrolysis is detected |
Trypanosoma cruzi |
o-aminobenzoyl-KLR + FSFQ-N-(2,4-dinitrophenyl)-ethylenediamine |
- |
? |
| 3.4.22.51 | more |
no substrate: benzyloxycarbonyl-Arg-Arg-aminomethyl coumarin |
Trypanosoma congolense |
? |
- |
? |
| 3.4.22.51 | Gelatin + H2O |
pH 5.5 or 10 |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O |
relatively low rates of substrate hydrolysis |
Trypanosoma rangeli |
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin |
- |
? |
| 3.4.22.51 | human IgG + H2O |
specific cleavage sites on human IgG subclasses by cruzipain |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | more |
stimulates potent humoral and cellular immune response during infection in both humans and mice |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | more |
substrate specificity of cruzipain 2 isoform is analysed using internally quenched flurogenic substrates. It is found that cruzipain 2 compared to cruzipain differs substantially regarding the specificity in the S2, S1' and S2' pockets, suggesting that cruzipain 2 acts on distinct natural substrates |
Trypanosoma cruzi |
? |
- |
? |
| 3.4.22.51 | more |
substrates are chromogenic peptides with a carboxyl Arg or Lys, enzyme requires at least one more amino acid, preferably Arg, Phe, Val or Leu between the terminal Arg or Lys and the amino-blocking group |
Trypanosoma cruzi |
? |
- |
? |
