EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.21.B43 | CCN4 protein + H2O |
- |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | CCN5 protein + H2O |
cleavage site is at Arg215-Val216 |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | CCN6 protein + H2O |
- |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | D-Val-Leu-Lys-thiobenzyl ester + H2O |
100% activity |
Homo sapiens |
D-Val-Leu-Lys + thiobenzyl alcohol |
- |
? |
3.4.21.B43 | Fibronectin + H2O |
- |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | Fibronectin + H2O |
the enzyme cleaves the human extracellular matrix proteins fibronectin and tenascin, both of which are involved in the regulation of endothelial cell adhesion and migration. KLK12-mediated fibronectin proteolysis antagonizes fibronectin polymerization and fibronectin fibril formation by endothelial cells, leading to an increase in cell migration |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | high molecular weight kininogen + H2O |
proteolysis pattern, overview. Release of bradykinin, a fragment containing the C-terminal end of kinins. The kininogenase activity of the enzyme is poor due to the resistance of hydrolysis of the K-R bond on the N-terminal side of the bradykinin sequence in the kininogen |
Homo sapiens |
? |
- |
? |
3.4.21.B43 | influenza hemagglutinin precursor + H2O |
the enzyme shows a preference for the H1 and H2 subtypes, the amino acids neighboring the arginine cleavage site affect cleavage efficiency |
Homo sapiens |
mature influenza hemagglutinin + ? |
- |
? |
3.4.21.B43 | influenza hemagglutinin precursor + H2O |
the enzyme shows a preference for the H1 and H2 subtypes, essentially no cleavage of the H3 subtype, the amino acids neighboring the arginine cleavage site affect cleavage efficiency |
Homo sapiens |
mature influenza hemagglutinin + ? |
- |
? |
3.4.21.B43 | more |
hormonal reglation of enzyme expression, overview |
Homo sapiens |
? |
- |
? |