EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.4.21.92 | more |
enzyme is required for release of autolysin A and pneumolysin. In vivo, it is required for growth of pneumococcus in the lungs and blood in a murine model of disease |
Streptococcus pneumoniae |
? |
- |
? |
| 3.4.21.92 | more |
enzyme is required for the growth at elevated temperature and for virulence |
Streptococcus pneumoniae |
? |
- |
? |
| 3.4.21.92 | more |
mucosal immunization with ClpP antigen induces both systemic and mucosal antibodies, and in this way reduces lung colonization in an invasive pneumococcal pneumonia model and also protects mice against death in an intraperitoneal-sepsis model. Intraperitoneal immunization of BALB/c mice with recombinant ClpP protein. ClpP protein is immunogenic in healthy children and is expressed during disease based on the elevated antibody levels in infected individuals. In vitro functional anti-ClpP antibody can kill streptococcus pneumoniae by polymorphonuclear leukocytes in a complement-dependent assay |
Streptococcus pneumoniae TIGR4 |
? |
- |
? |
| 3.4.21.92 | more |
nasal immunizations with ClpP and CbpA are efficient for induction of systemic and mucosal antibodies |
Streptococcus pneumoniae TIGR4 |
? |
- |
? |
| 3.4.21.92 | central competence regulator sigmax + H2O |
adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner |
Streptococcus thermophilus |
? |
- |
? |
| 3.4.21.92 | central competence regulator sigmax + H2O |
adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner |
Streptococcus thermophilus ATCC BAA-250 |
? |
- |
? |
| 3.4.21.92 | alpha-casein + H2O |
is completely degraded by ClpC and ClpP3/R within 20 min |
Synechococcus elongatus |
? |
- |
? |
| 3.4.21.92 | chlorophyll + H2O |
- |
Synechococcus elongatus |
? |
- |
? |
| 3.4.21.92 | FITC-casein + H2O |
neither ClpC nor ClpP3/R alone degrade FITC-casein but they do when added together. No proteolytic activity when ClpP3 alone is combined with ClpC |
Synechococcus elongatus |
? |
- |
? |
| 3.4.21.92 | FR-GFP + H2O |
ClpCP3/R with ClpS1 take over 20 min to completely degrade FR-GFP, whereas the ClpAP protease degrades all FR-GFP within 2 min |
Synechococcus elongatus |
? |
- |
? |
