EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.17.23 | angiotensin II + H2O |
primary substrate |
Mus musculus |
angiotensin-(1-7) + Phe |
- |
? |
| 3.4.17.23 | (7-methoxycoumarin-4-yl)acetyl-YVADAPK(2,4-dinitrophenyl)-OH + H2O |
synthetic fluorogenic caspase-1 substrate |
Homo sapiens |
(7-methoxycoumarin-4-yl)acetyl-YVADAP + N6-(2,4-dinitrophenyl)-L-lysine |
- |
? |
| 3.4.17.23 | TBC5046 + H2O |
synthetic fluorogenic peptide, i.e. des-Arg-bradykinin with N-terminal o-aminobenzoic acid and a 3-nitrophenylalanine instead of Phe at the C-terminus |
Homo sapiens |
o-aminobenzoic acid-des-Arg-bradykinin-(1-7) + 3-nitrophenylalanine |
- |
ir |
| 3.4.17.23 | (7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl)-OH + H2O |
synthetic fluorogenic substrate |
Homo sapiens |
(7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine |
- |
? |
| 3.4.17.23 | more |
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane |
Homo sapiens |
? |
- |
? |
| 3.4.17.23 | angiotensin I + H2O |
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited |
Homo sapiens |
angiotensin-(1-9) + Leu |
- |
? |
| 3.4.17.23 | more |
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited |
Homo sapiens |
? |
- |
? |
| 3.4.17.23 | more |
the enzyme has a function in blood pressure regulation, blood flow and fluid regulation. Loss of ACE2 impairs heart function |
Homo sapiens |
? |
- |
? |
| 3.4.17.23 | more |
the enzyme is involved in diesease condition including hypertension, diabetes and cardiac function. ACE2 is the SARS virus receptor |
Homo sapiens |
? |
- |
? |
| 3.4.17.23 | angiotensin II + H2O |
the enzyme is involved in the renin angiotensin system |
Homo sapiens |
angiotensin-(1-7) + L-Phe |
- |
? |
