EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Saccharomyces cerevisiae |
leukotriene B4 |
- |
? |
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Xenopus laevis |
leukotriene B4 |
- |
? |
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Cavia porcellus |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Mus musculus |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Homo sapiens |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
3.3.2.6 | leukotriene A4 + H2O |
model for the binding of leukotriene A4 to the active site |
Rattus norvegicus |
leukotriene B4 |
mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% |
? |
3.3.2.6 | leukotriene A4 + H2O |
one of the physiologically important processes in the arachidonic acid biosynthetic pathway, leukotriene B4 is a proinflammatory mediator which stimulates adhesion of circulating neutrophils to vascular endothelium and directs their migration towards sites of inflammation |
Homo sapiens |
leukotriene B4 |
- |
? |
3.3.2.6 | leukotriene A4 + H2O |
central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation |
Homo sapiens |
leukotriene B4 |
- |
? |
3.3.2.6 | leukotriene A4 + H2O |
biosynthesis of leukotriene B4 |
Homo sapiens |
leukotriene B4 |
- |
? |
3.3.2.6 | leukotriene A4 + H2O |
biosynthesis of leukotriene B4 |
Rattus norvegicus |
leukotriene B4 |
- |
? |