EC Number   |
Substrates  |
Organism |
Products |
Reversibility |
|---|
   2.7.8.43 | more |
the enzyme modifies lipid A with one or two phosphoethanolamine moieties. Six lipid A substrate subtypes, St1 to St6, from wild type Salmonella typhimurium are covalently modified with one or two 4-amino-4-deoxy-L-arabinose moieties. Each lipid A species with a defined set of polar modifications can be further derivatized with a palmitoyl moiety and/or a 2-hydroxymyristoyl residue in place of the secondary myristoyl chain at position 3', high resolution NMR spectroscopy and mass spectrometry analysis of lipid A profiles from wild-type strain 14028 and mutant strains, overview |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 |
? |
- |
? |
| 2.7.8.43 | more |
lipid A substrate and product analysis by MALDI-TOF/MS. The lipidA preparations from transgenic Escherichia coli strains carrying EptA show additional ions due to the addition of phosphoethanolamine to the bis-phosphorylatedstructure and the hepta-acylated structure |
Shewanella algae MARS 14 |
? |
- |
? |
| 2.7.8.43 | more |
enzyme activity assays on the membrane-deleted LptA are performed using 4-nitrophenyl phosphoethanolamine, p-NPPE, as the substrate analogue, the enzyme is capable of cleaving the phosphoethanolamine portion from the p-NPPE chromogenic substrate |
Neisseria meningitidis NMB |
? |
- |
? |
| 2.7.8.43 | more |
phosphoethanolamine substitution at both the 1 and 4' positions of lipid A, component of lipooligosaccharide. Lipooligosaccharide structure analysis by MALDI-TOF mass spectrometry, overview |
Neisseria gonorrhoeae FA19 |
? |
- |
? |
| 2.7.8.43 | more |
enzyme EptA catalyses the periplasmic addition of the positively charged substituent phosphoethanolamine to lipid A controlled by the PmrA transcriptional regulator and conferring resistance to cationic antimicrobial peptides, including polymyxin |
Salmonella enterica LT2 |
? |
- |
? |
| 2.7.8.43 | more |
enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide |
Campylobacter jejuni 81-176 |
? |
- |
? |
| 2.7.8.43 | more |
pEtN transferase, EptC, modifies an array of cell-surface molecules and the N-linked glycans of numerous glycoproteins |
Campylobacter jejuni 81-176 |
? |
- |
? |
