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Results 11 - 16 of 16

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.7.7.86	ATP + GTP	over 78% conversion within 40 min	Mus musculus	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?
2.7.7.86	ATP + GTP	overall reaction	Mus musculus C57BL/6J	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?
2.7.7.86	more	interaction of cGAS and viral DNA sensor IFI16, the pyrin domain of IFI16 mediates the interaction with ND10 bodies and enzyme cGAS	Homo sapiens	?	-	-
2.7.7.86	more	a diphosphatase-coupled cGAS activity assay is performed	Homo sapiens	?	-	-
2.7.7.86	more	quantification of cyclic Gp(2'-5')Ap(3'-5')(2',3'-cGAMP)WS is performed by LC-MS/MS	Homo sapiens	?	-	-
2.7.7.86	more	the substrate orientation is thermodynamically preferred for 2',3'-cGAMP, kinetics, overview. cGAS can produce 2',3'-cGAMP without releasing AMP-2'-GTP to solution. AMP-2'-GTP is produced in significant abundance initially, while 2',3'-cGAMP is not	Homo sapiens	?	-	-

Results 11 - 16 of 16

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Release 2023.1 (January 2023)