2.7.7.86	ATP + GTP	-	Homo sapiens	2 diphosphate + cyclic 3',5'-AMP-GMP	-	?	421874	
2.7.7.86	ATP + GTP	-	Mus musculus	2 diphosphate + cyclic 3',5'-AMP-GMP	-	?	421874	
2.7.7.86	ATP + GTP	cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines	Homo sapiens	2 diphosphate + cyclic 3',5'-AMP-GMP	-	?	421874	
2.7.7.86	ATP + GTP	cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines	Mus musculus	2 diphosphate + cyclic 3',5'-AMP-GMP	-	?	421874	
2.7.7.86	ATP + GTP	-	Homo sapiens	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	ATP + GTP	-	Homo sapiens	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	product is cyclic Gp(2'-5')Ap(3'-5')	?	424671	
2.7.7.86	ATP + GTP	-	Mus musculus	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	product is cyclic Gp(2'-5')Ap(3'-5')	?	424671	
2.7.7.86	ATP + GTP	overall reaction	Homo sapiens	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	ATP + GTP	overall reaction	Mus musculus	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	ATP + GTP	overall reaction	Gallus gallus	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	ATP + GTP	over 78% conversion within 40 min	Mus musculus	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	ATP + GTP	overall reaction	Mus musculus C57BL/6J	2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')	-	?	424671	
2.7.7.86	additional information	interaction of cGAS and viral DNA sensor IFI16, the pyrin domain of IFI16 mediates the interaction with ND10 bodies and enzyme cGAS	Homo sapiens	?	-	-	89	
2.7.7.86	additional information	a diphosphatase-coupled cGAS activity assay is performed	Homo sapiens	?	-	-	89	
2.7.7.86	additional information	quantification of cyclic Gp(2'-5')Ap(3'-5')(2',3'-cGAMP)WS is performed by LC-MS/MS	Homo sapiens	?	-	-	89	
2.7.7.86	additional information	the substrate orientation is thermodynamically preferred for 2',3'-cGAMP, kinetics, overview. cGAS can produce 2',3'-cGAMP without releasing AMP-2'-GTP to solution. AMP-2'-GTP is produced in significant abundance initially, while 2',3'-cGAMP is not	Homo sapiens	?	-	-	89