EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.10.2 | more |
Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview |
Pseudomonas aeruginosa |
? |
- |
? |
| 2.7.10.2 | more |
SH2 domain-based tyrosine kinase assay using biotin ligase modified with a terbium(III) complex. An SH2 domain from lymphocyte-specific tyrosine kinase is genetically fused to a truncated biotin carboxyl carrier protein, and the resulting fusion protein is labeled through biotinylation with biotin protein ligase carrying multiple copies of a luminescent Tb3+ complex. The labeled SH2 fusion proteins are employed to detect a phosphorylated peptide immobilized on the surface of the microtiter plate, where the phosphorylated peptide is produced by phosphorylation to the substrate peptide by Src tyrosine kinase. The assay allows for a reliable determination of the activity of Src kinase lower than 10 ng/mL |
Sulfurisphaera tokodaii |
? |
- |
? |
| 2.7.10.2 | more |
after platelet stimulation, integrin alphaIIbbeta3 binds to the enzyme's SH3 domain at a site overlapping with its PPII helix binding site |
Homo sapiens |
? |
- |
? |
| 2.7.10.2 | more |
the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity |
Mus musculus C57BL/6 |
? |
- |
? |
| 2.7.10.2 | more |
p40mos binds ATP analog p-fluorosulfonylbenzoyladenosine and exhibits ATPase activity |
Moloney murine sarcoma virus HT-1 |
? |
- |
? |
| 2.7.10.2 | more |
oncogene v-fps induces fibrosarcomas in birds |
Avian sarcoma virus PRCII |
? |
- |
? |
| 2.7.10.2 | p130Cas + ATP |
phosphorylation of the Crk and Nck adaptor protein by Fak |
Homo sapiens |
phospho-tyrosinyl p130Cas + ADP |
- |
? |
| 2.7.10.2 | paxillin + ATP |
phosphorylation at Tyr31 and Tyr118 by Fak plays a role in tumor cell motility inhibition |
Homo sapiens |
phospho-tyrosinyl paxillin + ADP |
- |
? |
| 2.7.10.2 | paxillin + ATP |
phosphorylation at Tyr31 and Tyr118 by Fak |
Homo sapiens |
phospho-tyrosinyl paxillin + ADP |
- |
? |
| 2.7.10.2 | STAT transcription activator protein + ATP |
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview |
Drosophila melanogaster |
phosphorylated STAT transcription activator protein + ADP |
- |
? |
