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Results 31 - 34 of 34

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.4.1.B72	more	the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated	Toxoplasma gondii ATCC 50861	?	-	-
2.4.1.B72	UNC5A + GDP-mannose	C-mannosylation of murine UNC5A	Caenorhabditis elegans	C-mannosyl-UNC5A + GDP	-	?
2.4.1.B72	UNC5A + GDP-mannose	C-mannosylation of murine UNC5A, DPY19L1 can C-mannosylate the first two tryptophans in the WxxWxxWxxC sequence of UNC5A TSRs	Mus musculus	C-mannosyl-UNC5A + GDP	-	?
2.4.1.B72	UNC5A + GDP-mannose	C-mannosylation of murine UNC5A, DPY19L3 mannosylates the third tryptophan of this sequence and might require a WxxC motif	Mus musculus	C-mannosyl-UNC5A + GDP	-	?

Results 31 - 34 of 34

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Release 2023.1 (January 2023)