EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.4.1.144 | more |
cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells |
Mus musculus |
? |
- |
? |
| 2.4.1.144 | more |
N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
expression of GnTIII leads to a high proportion of N-glycans of the complex type, modified with the bisecting GlcNAc (median value 37%, q1, 33%, q3, 39%) and a strong reduction of paucimannosidic type N-glycans (median value 2%, q1, 1%, q3.2%) that are abundant in secreted proteins of tobacco BY-2 cells. Native GnTIII expression, the coexpression of Arabidopsis thaliana ManII leads to an increase in the proportion of complex bisected N-glycan structures, whereas the expression of native human ManII does not significantly increase these structures. In the case of chimeric GnTIIIA.th. and chimeric ManIIA.th. expression, reduction in hybrid bisected structures. No viable cultures expressing GnTIIIA.th. and A. thaliana ManII. Plant-specific core fucosylation and xylosylation can be greatly reduced, with up to 59% of N-glycans on endogenous secreted protein lacking the plant-specific modifications |
Rattus norvegicus |
? |
- |
? |
| 2.4.1.144 | more |
GnT-III selectively modifies N-glycosylation site-4 on the integrin alpha5 subunit (S-3,4,5), which down-regulates its biological functions |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
N-glycosylation of laminin-332, GnT-III down-regulates activities of laminin-332 |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
the enzyme catalyzes the transfer of N-acetylglucosamine in a beta1,4 linkage to mannose on N-glycans forming a bisecting N-acetylglucosamine structure |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
the enzyme introduces a N-acetylglucosamine in a beta1,4-linkage to the mannose residue located at the base of the trimannosyl core (bisecting N-acetylglucosamine) in N-glycans |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | more |
the MCAM glycoprotein, which is a biomarker of cutaneous melanoma, as a potential target for overexpressed glycosyltransferases |
Homo sapiens |
? |
- |
? |
| 2.4.1.144 | UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(beta-D-glucosyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R |
GnT-III catalyzes the removal of the bisecting GlcNAc from the bisected oligosaccharide, producing the corresponding nonbisected sugar chain |
Rattus norvegicus |
UDP-D-glucose + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R |
- |
r |
