EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
4.2.1.108 | more |
phylogenetic analysis |
Sporosarcina pasteurii |
? |
- |
? |
4.2.1.108 | more |
phylogenetic analysis |
Virgibacillus salexigens |
? |
- |
? |
4.2.1.108 | more |
phylogenetic analysis |
Chromohalobacter salexigens |
? |
- |
? |
4.2.1.108 | more |
the enzyme is osmoregulated in response to medium salinity allowing the organism to live in environments with high concentration of osmolytes |
Marinococcus halophilus |
? |
- |
? |
4.2.1.108 | more |
ectoine synthase accepts more than one substrate and is a reversible enzyme able to catalyze both the intramolecular condensation into and the hydrolytic cleavage of cyclic amino acid derivatives. It forms 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylate, ADPC, by cyclic condensation of glutamine in a reversible reaction. A number of ectoine derivatives, in particular 4,5-dihydro-2-methylimidazole-4-carboxylate and L-homoectoine, are also cleaved by ectoine synthase. Proposed reaction mechanism leading to L-ectoine and 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylate, respectively, catalyzed by ectoine synthase, overview |
Halomonas elongata |
? |
- |
? |
4.2.1.108 | more |
EctC not only effectively converts its natural substrate N-gamma-acetyl-L-2,4-diaminobutyric acid into ectoine through a cyclocondensation reaction, but it can also use the isomer N-alpha-acetyl-L-2,4-diaminobutyric acid as its substrate, albeit with substantially reduced catalytic efficiency |
Sphingopyxis alaskensis |
? |
- |
? |
4.2.1.108 | more |
EctC not only effectively converts its natural substrate N-gamma-acetyl-L-2,4-diaminobutyric acid into ectoine through a cyclocondensation reaction, but it can also use the isomer N-alpha-acetyl-L-2,4-diaminobutyric acid as its substrate, albeit with substantially reduced catalytic efficiency |
Sphingopyxis alaskensis DSM 13593 / LMG 18877 / RB2256 |
? |
- |
? |
4.2.1.108 | more |
ectoine synthase accepts more than one substrate and is a reversible enzyme able to catalyze both the intramolecular condensation into and the hydrolytic cleavage of cyclic amino acid derivatives. It forms 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylate, ADPC, by cyclic condensation of glutamine in a reversible reaction. A number of ectoine derivatives, in particular 4,5-dihydro-2-methylimidazole-4-carboxylate and L-homoectoine, are also cleaved by ectoine synthase. Proposed reaction mechanism leading to L-ectoine and 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylate, respectively, catalyzed by ectoine synthase, overview |
Halomonas elongata DSM 2581 |
? |
- |
? |
4.2.1.108 | (2S)-4-acetamido-2-aminobutanoate |
- |
Sphingopyxis alaskensis |
L-ectoine + H2O |
- |
? |
4.2.1.108 | (2S)-4-acetamido-2-aminobutanoate |
i.e. N-gamma-acetyl-L-2,4-diaminobutanoate |
Sphingopyxis alaskensis |
L-ectoine + H2O |
- |
? |