EC Number   |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
|---|
    2.3.1.57 | -999 |
- |
- |
487256, 487262, 487263, 487266, 487267, 660954, 662129, 702136 |
| 2.3.1.57 | -999 |
- |
kinetic and mechanistic characterization, determination of bisubstrate inhibition patterns, three-dimensional structure of the recombinant human SSAT protein with bound bisubstrate inhibitor, acid/base assisted reaction catalyzed by SSAT involves a ternary complex, proposed on the base of kinetic properties, pH dependence and structure analysis |
685168 |
| 2.3.1.57 | -999 |
- |
polyamine content in different clones of a transfected rat epidermal cell line expressing the enzyme, overview |
662583 |
| 2.3.1.57 | -999 |
- |
regulation of SSAT expression, de novo RNA and protein synthesis analyzed, two regions of the SSAT protein coding sequence involved in translational repression of SSAT in the absence of elevated polyamine levels, RNA-binding protein possibly interacting with stem-loop structures to block translation can be displaced by the polyamine analogue N1,N11-bis-(ethyl)-norspermine (DENSPM), allowing translation to proceed, 5' and 3' polyamine-responsive regions interact with each other in vivo, changes in either region result in translation in the absence of the polyamine analogue N1,N11-bis-(ethyl)-norspermine |
687614 |
| 2.3.1.57 | -999 |
- |
SSAT1 inhibits hypoxia-inducible factor-1 (HIF-1alpha) through protein/protein interaction, effect of SSAT1 loss of function on HIF-1alpha protein levels and HIF-1 transcriptional activity, mutation of Arg101 impairs SSAT1-mediated HIF-1alpha degradation, SSAT1 promotes the ubiquitination of HIF-1alpha, involvement of SSAT1 and SSAT2 in alternative pathways for ubiquitination and degradation of HIF-1alpha, complementary roles in promoting O2-independent and O2-dependent degradation of HIF-1alpha |
687634 |
| 2.3.1.57 | -999 |
- |
structure of polyamine fragment of the conjugate important for enzyme activity, existence of adenosine groups crucial for effective inhibition, since conjugates of D-N-pantothenylamidoethyl mercaptane family reveals low inhibitory activities, most exact mimic of the intermediate of N1-acetyltransferase reaction less active than analogue of the intermediate of N8-acetyltransferase reaction, significant contribution of the polyamine fragment into inhibition proven by lower activity |
689266 |
| 2.3.1.57 | -999 |
- |
tumor progression in transgenic mice expressing SSAT depends on elevated activity of ornithine decarboxylase (ODC) and on increased putrescine levels, strategy to modulate polyamine levels through the inhibition of ornithine decarboxylase (ODC) activity or polyamine uptake, but not via increased SSAT expression for cancer chemoprevention |
685968 |
| 2.3.1.57 | 0.000003 |
0.00008 |
activity in different clones of a transfected rat epidermal cell line expressing the enzyme |
662583 |
| 2.3.1.57 | 0.0000035 |
- |
recombinant EGFP-tagged SSAT in cells |
702136 |
| 2.3.1.57 | 0.00007 |
- |
recombinant HEK-293 cells expressing isozyme SSAT-2, substrate putrescine |
660954 |
