BRENDA - Enzyme Database
show all sequences of 2.3.1.57

Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase

Hegde, S.S.; Chandler, J.; Vetting, M.W.; Yu, M.; Blanchard, J.S.; Biochemistry 46, 7187-7195 (2007) View publication on PubMedView publication on EuropePMC

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli, strains Nova Blue and BL21(DE3), plasmid pET-28a
Homo sapiens
Crystallization (Commentary)
Crystallization (Commentary)
Organism
three-dimensional crystal structure of SSAT with bound bisubstrate inhibitor, solved at 2.3 A resolution, hanging drop method, data and refinement statistics
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
N1-spermine-acetyl-CoA
bisubstrate analogue, bisubstrate inhibition patterns determined, linear, competitive inhibition against sperimidine and acetyl-CoA determined
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
no detectable activity for putrescine and cadaverine
Homo sapiens
0.0038
-
acetyl-CoA
measured at fixed saturating concentration of spermidine
Homo sapiens
0.0057
-
spermine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.022
-
spermidine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.107
-
1,3-diaminopropane
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.194
-
diethylenetriamine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.196
-
ethylenediamine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acetyl-CoA + spermidine
Homo sapiens
-
CoA + N1-acetylspermidine
-
-
?
acetyl-CoA + spermine
Homo sapiens
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells
CoA + N1-acetylspermine
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
P21673
hSSAT gene
-
Purification (Commentary)
Purification (Commentary)
Organism
gel filtration, recombinant protein, all purification procedures at 4°C
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
commercial preparation
cDNA clone of human SSAT
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
kinetic and mechanistic characterization, determination of bisubstrate inhibition patterns, three-dimensional structure of the recombinant human SSAT protein with bound bisubstrate inhibitor, acid/base assisted reaction catalyzed by SSAT involves a ternary complex, proposed on the base of kinetic properties, pH dependence and structure analysis
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
acetyl-CoA + 1,3-diaminopropane
-
685168
Homo sapiens
CoA + N1-acetyl-1,3-diaminopropane
-
-
-
?
acetyl-CoA + diethylenetriamine
-
685168
Homo sapiens
CoA + N1-acetyl-diethylenetriamine
-
-
-
?
acetyl-CoA + ethylenediamine
-
685168
Homo sapiens
CoA + N1-acetyl-ethylenediamine
-
-
-
?
acetyl-CoA + spermidine
-
685168
Homo sapiens
CoA + N1-acetylspermidine
-
-
-
?
acetyl-CoA + spermine
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells
685168
Homo sapiens
CoA + N1-acetylspermine
-
-
-
?
acetyl-CoA + spermine
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells, chemical and kinetic mechanism for acetyl transfer activity by recombinant human SSAT protein proposed
685168
Homo sapiens
CoA + N1-acetylspermine
-
-
-
?
chloroacetyl-CoA + spermine
N1-chloroacetylation of spermine performed by hSSAT protein, pH 7.5 and 2 microM recombinant human SSAT protein at room temperature for one hour, identity of the product confirmed by mass spectrometry
685168
Homo sapiens
N1-spermine-acetyl-CoA + ?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
SSAT
-
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
determined by pH activity profile
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.7
9.1
activity monitored every 0.3 pH units, bell shaped pH activity profile, depending on ionization state of two groups with apparent pKa values of 7.27 and 8.87
Homo sapiens
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.006
-
N1-spermine-acetyl-CoA
bisubstrate analogue, linear, competitive inhibition, structure of hSSAT with bound N1-spermine-acetyl-CoA determined
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli, strains Nova Blue and BL21(DE3), plasmid pET-28a
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
three-dimensional crystal structure of SSAT with bound bisubstrate inhibitor, solved at 2.3 A resolution, hanging drop method, data and refinement statistics
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
N1-spermine-acetyl-CoA
bisubstrate analogue, bisubstrate inhibition patterns determined, linear, competitive inhibition against sperimidine and acetyl-CoA determined
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.006
-
N1-spermine-acetyl-CoA
bisubstrate analogue, linear, competitive inhibition, structure of hSSAT with bound N1-spermine-acetyl-CoA determined
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
no detectable activity for putrescine and cadaverine
Homo sapiens
0.0038
-
acetyl-CoA
measured at fixed saturating concentration of spermidine
Homo sapiens
0.0057
-
spermine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.022
-
spermidine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.107
-
1,3-diaminopropane
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.194
-
diethylenetriamine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
0.196
-
ethylenediamine
measured at fixed saturating concentrations of acetyl-CoA
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acetyl-CoA + spermidine
Homo sapiens
-
CoA + N1-acetylspermidine
-
-
?
acetyl-CoA + spermine
Homo sapiens
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells
CoA + N1-acetylspermine
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
gel filtration, recombinant protein, all purification procedures at 4°C
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
commercial preparation
cDNA clone of human SSAT
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
kinetic and mechanistic characterization, determination of bisubstrate inhibition patterns, three-dimensional structure of the recombinant human SSAT protein with bound bisubstrate inhibitor, acid/base assisted reaction catalyzed by SSAT involves a ternary complex, proposed on the base of kinetic properties, pH dependence and structure analysis
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
acetyl-CoA + 1,3-diaminopropane
-
685168
Homo sapiens
CoA + N1-acetyl-1,3-diaminopropane
-
-
-
?
acetyl-CoA + diethylenetriamine
-
685168
Homo sapiens
CoA + N1-acetyl-diethylenetriamine
-
-
-
?
acetyl-CoA + ethylenediamine
-
685168
Homo sapiens
CoA + N1-acetyl-ethylenediamine
-
-
-
?
acetyl-CoA + spermidine
-
685168
Homo sapiens
CoA + N1-acetylspermidine
-
-
-
?
acetyl-CoA + spermine
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells
685168
Homo sapiens
CoA + N1-acetylspermine
-
-
-
?
acetyl-CoA + spermine
N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) crucial for regulation of the cellular polyamine levels in eukaryotic cells, chemical and kinetic mechanism for acetyl transfer activity by recombinant human SSAT protein proposed
685168
Homo sapiens
CoA + N1-acetylspermine
-
-
-
?
chloroacetyl-CoA + spermine
N1-chloroacetylation of spermine performed by hSSAT protein, pH 7.5 and 2 microM recombinant human SSAT protein at room temperature for one hour, identity of the product confirmed by mass spectrometry
685168
Homo sapiens
N1-spermine-acetyl-CoA + ?
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
determined by pH activity profile
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.7
9.1
activity monitored every 0.3 pH units, bell shaped pH activity profile, depending on ionization state of two groups with apparent pKa values of 7.27 and 8.87
Homo sapiens
Other publictions for EC 2.3.1.57
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755723
Filippova
Analysis of crystalline and s ...
Escherichia coli
Acta Crystallogr. Sect. D
75
545-553
2019
-
-
1
1
-
-
-
-
-
-
2
1
-
4
-
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1
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1
1
2
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1
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1
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1
1
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757687
Li
Polyamine-independent growth ...
Enterococcus faecalis, Staphylococcus aureus, Staphylococcus aureus USA300
Mol. Microbiol.
111
159-175
2019
-
-
1
-
-
-
-
4
-
-
-
6
-
14
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1
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10
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6
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1
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6
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1
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-
-
10
-
-
-
-
4
-
-
-
-
-
-
-
-
4
4
757876
Thakur
Spermidine/spermine N1-acetyl ...
Homo sapiens
Oncogene
38
6794-6800
2019
-
1
1
-
-
-
-
-
-
-
-
2
-
1
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-
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-
1
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2
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2
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1
1
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1
-
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2
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
756851
Maksymiuk
Spermidine/spermine N1-acetyl ...
Homo sapiens
Future Sci. OA
4
FSO345
2018
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
10
-
-
1
-
2
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-
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1
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1
-
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-
-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
757571
Yuan
Spermidine/spermine N1-acetyl ...
Mus musculus
Metab. Clin. Exp.
85
298-304
2018
1
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
-
-
2
-
3
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1
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2
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1
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2
-
-
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-
-
-
-
-
-
1
2
2
1
-
-
758176
Hu
The spermidine acetyltransfer ...
Escherichia coli
PLoS ONE
13
e0207563
2018
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
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1
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2
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3
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1
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1
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1
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-
2
-
-
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-
-
-
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-
-
-
2
2
-
-
-
757344
Kobayashi
Bacterial degradation of sper ...
Bacillus subtilis subsp. natto, Bacillus subtilis subsp. natto BEST195
J. Gen. Appl. Microbiol.
63
373-376
2017
-
-
-
-
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2
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4
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2
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-
-
-
-
-
1
-
-
1
-
-
757889
Wang
Spermidine/spermine N1-acetyl ...
Homo sapiens
Oncotarget
8
1092-1109
2017
-
-
-
-
-
-
-
-
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2
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1
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7
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2
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7
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2
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-
-
1
1
1
1
-
-
735996
Weigand
Small angle X-ray scattering d ...
Escherichia coli
Data Brief
6
47-52
2016
-
-
-
1
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-
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-
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756390
Mounce
Interferon-induced spermidine ...
Homo sapiens
Cell Host Microbe
20
167-177
2016
-
-
-
-
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-
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-
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2
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6
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2
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1
1
1
1
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756930
Sugiyama
Molecular mechanism underlyin ...
Escherichia coli, Escherichia coli LY180
Int. J. Biochem. Cell Biol.
76
87-97
2016
-
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1
1
13
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13
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735640
Mandal
Depletion of the polyamines sp ...
Homo sapiens
Biochem. J.
468
435-447
2015
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1
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1
1
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736639
Filippova
A novel polyamine allosteric s ...
Vibrio cholerae, Vibrio cholerae N16961
J. Mol. Biol.
427
1316-1334
2015
-
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-
1
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1
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1
4
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10
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6
2
3
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1
1
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4
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6
2
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4
4
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736641
Filippova
Substrate-induced allosteric c ...
Vibrio cholerae, Vibrio cholerae N16961
J. Mol. Biol.
427
3538-3553
2015
-
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1
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1
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2
4
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7
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6
1
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1
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4
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6
1
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2
2
-
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-
737285
Pirnes-Karhu
Overexpression of spermidine/s ...
Mus musculus, Mus musculus C57BL/6JOlaHsd
Transgenic Res.
24
253-265
2015
-
-
1
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-
-
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7
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4
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1
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1
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1
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Inhibition of spermidine/sperm ...
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3
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1
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1
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1
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Stable analogues of coenzyme-s ...
Homo sapiens
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11
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2
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1
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11
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2
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2
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735387
Niiyama
Expression, purification, crys ...
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1
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1
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736007
Hyvoenen
Metabolism of triethylenetetra ...
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2
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9
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1
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2
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8
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2
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9
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3
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736271
Squassina
Differential effect of lithium ...
Homo sapiens
Int. J. Neuropsychopharmacol.
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2
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737100
Lien
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2
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1
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6
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13
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718544
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718560
Hyvoenen
Tissue-specific alternative sp ...
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Characterization of and functi ...
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Uimari
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702524
Fiori
Identification and characteriz ...
Homo sapiens
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703928
Marverti
Spermidine/spermine N1-acetylt ...
Homo sapiens
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Stanic
The polyamine analogue N1,N11- ...
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701622
Pegg
Spermidine/spermine-N1-acetylt ...
Homo sapiens, Mus musculus, Rattus norvegicus
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701662
Takao
Measurement of spermidine/sper ...
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1
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702246
Montemayor
The crystal structure of sperm ...
Mus musculus
Biochemistry
47
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2008
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1
2
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703097
Holst
Subcellular distribution of sp ...
Homo sapiens
Cell Biol. Int.
32
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704455
Kramer
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Sun
Adenovirus-mediated expression ...
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671226
Zahedi
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Homo sapiens
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Genetically altered expression ...
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The role of spermidine/spermin ...
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Hegde
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689266
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Novel CoA-polyamine conjugates ...
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Spermidine/spermine N1-acetylt ...
Homo sapiens
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676840
Bewley
Structures of wild-type and mu ...
Homo sapiens
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677093
Hyvoenen
Polyamine-regulated unproducti ...
Mus musculus
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1
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661429
Tucker
Potent modulation of intestina ...
Mus musculus
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Disturbed keratinocyte differe ...
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1
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1
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3
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7
2
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3
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1
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672937
Marverti
Spermidine/spermine N1-acetylt ...
Homo sapiens
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26
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1
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1
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4
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1
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Bacillus subtilis
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5
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1
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1
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5
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1
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Genomic identification and bio ...
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2
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2
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3
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6
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2
17
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15
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2
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2
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Expression of spermidine/sperm ...
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1
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1
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1
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1
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Properties of the spermidine/s ...
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1
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4
1
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1
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1
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1
1
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4
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1
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1
3
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2
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1
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487268
Coleman
Polyamine analogues inhibit th ...
Homo sapiens
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7
1
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1
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1
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16
1
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2
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1
4
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1
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7
1
1
-
-
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-
-
-
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487269
Bras
Spermidine/spermine N1-acetylt ...
Mus musculus
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29
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2001
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2
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1
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3
2
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1
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1
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3
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1
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487270
Turchanowa
Nonsteroidal anti-inflammatory ...
Homo sapiens
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1
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1
1
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2
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6
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487266
Vujcic
Effects of conditional overexp ...
Homo sapiens, Mus musculus
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12
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2
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12
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487267
Alhonen
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1
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Ignatenko
-
Expression of the human spermi ...
Homo sapiens
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3
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-
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487263
Parry
Effect of expression of human ...
Homo sapiens
Biochemistry
34
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1995
2
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1
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2
1
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3
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1
1
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2
1
11
1
1
-
-
-
-
-
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-
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-
-
-
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487262
Quick
Induction of spermidine/spermi ...
Homo sapiens
Biochem. Pharmacol.
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969-974
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1
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6
1
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1
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2
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1
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6
1
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3
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487265
Gerner
-
Stress induction of the spermi ...
Cricetulus griseus, Homo sapiens
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294
491-495
1993
2
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3
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8
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2
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2
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8
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487260
Wittich
Putrescine N-acetyltransferase ...
Ascaris suum, Onchocerca volvulus
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38
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1990
-
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18
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2
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2
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2
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2
2
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18
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487259
Wittich
A novel type of putrescine (di ...
Ascaris suum
Biochem. J.
260
265-269
1989
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1
2
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10
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2
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2
1
2
11
1
-
1
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2
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1
1
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1
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-
-
-
-
-
-
1
-
2
1
4
1
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2
1
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2
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2
1
2
11
1
1
-
2
-
1
1
-
-
-
-
-
-
-
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487256
Haywood
The occurrence, subcellular lo ...
[Candida] boidinii, [Candida] methanosorbosa, Trichosporon melibiosaceum, [Candida] methanosorbosa CBS 6853, [Candida] boidinii CBS 5777, Trichosporon melibiosaceum CBS 6087
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3
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17
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1
3
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2
1
27
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1
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1
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2
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1
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1
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4
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11
3
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3
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1
-
-
2
1
27
-
1
-
1
-
2
-
1
-
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-
-
-
-
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487258
Della Ragione
Spermidine N1-acetyltransferas ...
Rattus norvegicus
Methods Enzymol.
94
321-325
1983
2
-
-
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2
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1
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2
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1
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1
1
1
10
1
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1
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1
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1
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2
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1
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2
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1
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2
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1
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1
1
1
10
1
1
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1
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-
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-
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487257
Della Ragione
Purification and characterizat ...
Rattus norvegicus
Biochemistry
21
6152-6158
1982
1
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1
4
6
1
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2
2
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4
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1
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3
1
1
9
1
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1
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3
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1
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1
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1
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4
1
6
1
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2
2
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1
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3
1
1
9
1
1
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3
-
-
-
-
-
-
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-
-
-
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487261
Seiler
Acetyl-CoA:1,4-diaminobutane N ...
Rattus norvegicus
Biochim. Biophys. Acta
354
206-212
1974
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-
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6
1
2
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1
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4
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
1
2
-
-
-
-
-
-
-
-
4
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-