EC Number   |
Source Tissue |
Reference |
|---|
   1.6.3.1 | aorta |
aortic rings |
685982 |
| 1.6.3.1 | aorta |
cultured aortic smooth muscle cell |
684269 |
| 1.6.3.1 | aorta |
Exposure of mouse aortic rings to hypoxia/reoxygenation significantly increases vessel outgrowth, whereas pharmacological inhibition of NADPH oxidase or genetic deletion of the NADPH oxidase subunit, p47phox significantly suppresses these changes. Increases in myocardial serine-threonine kinase Akt and ERK1/2 activation and vascular endothelial growth factor expression are markedly blunted in the subunit p47phox-deficient mouse subjected to myocardial ischemia-reperfusion compared with the wild-type mouse |
684345 |
| 1.6.3.1 | aorta |
hemin treatment increases hemin oxidase-1 expression and activity in aorta and kidney of apolipoprotein E-deficient mice and significantly reduces both NADPH oxidase activity and superoxide generation in situ. Effects are reversed by tin protoporphyrin-IX and are not associated with changes in isoforms Nox2 or Nox4 protein levels. Inhibition of NADPH oxidase activity by hemin in the aorta is mimicked by bilirubin in vitro |
687050 |
| 1.6.3.1 | aortic endothelial cell |
- |
711688, 711763 |
| 1.6.3.1 | aortic smooth muscle cell |
- |
711688 |
| 1.6.3.1 | aortic smooth muscle cell |
commercial preparation |
688446 |
| 1.6.3.1 | artery |
- |
685976, 710782 |
| 1.6.3.1 | artery |
coronary artery endothelial cells |
687649 |
| 1.6.3.1 | artery |
human pulmonary artery endothelial cell, induction of NAD(P)H oxidase by exposure to hyperoxia for 3 h. Pretreatment of cells with the actin-stabilizing agent phallacidin attenuates hyperoxia-induced cortical actin thickening and reactive oxygen species production, whereas cytochalasin D and latrunculin A enhance basal and hyperoxia-induced reactive oxygen species formation. A 3-h hyperoxic exposure enhances the tyrosine phosphorylation of cortactin and interaction between cortactin and subunit p47phox. Transfection of cells with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated reactive oxygen species production and the hyperoxia-induced translocation of p47phox to the cell periphery |
687587 |
