Literature summary for 1.6.3.1 extracted from

Chan, E.C.; Datla, S.R.; Dilley, R.; Hickey, H.; Drummond, G.R.; Dusting, G.J.
Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits (2007), Cardiovasc. Res., 75, 710-718.

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Application

Application	Comment	Organism
medicine	after 14 days, local treatment with apocynin via the adventitia, reduces superoxide generation. Apocynin significantly reduces neointima formation and proliferation of cells in both the neointima and adventitia. Nitric oxide-dependent vasorelaxation to acetylcholine, which is normally impaired in collared arteries, is improved, and apocynin suppresses the endothelial expression of intracellular adhesion molecule- and vascular cell adhesion molecule-	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	after 14 days, local treatment with apocynin via the adventitia, reduces superoxide generation. Apocynin significantly reduces neointima formation and proliferation of cells in both the neointima and adventitia. Nitric oxide-dependent vasorelaxation to acetylcholine, which is normally impaired in collared arteries, is improved, and apocynin suppresses the endothelial expression of intracellular adhesion molecule- and vascular cell adhesion molecule-	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	-	Oryctolagus cuniculus	-

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Release 2023.1 (January 2023)