EC Number   |
General Information |
Reference |
|---|
    4.2.1.157 | evolution |
Mycobacterium tuberculosis strain H37Ra describes a 1 bp insertion in the MRA0648 gene, the orthologue of the Rv0637 (hadC) gene of Mycobacterium tuberculosis strain H37Rv |
-, 748687 |
| 4.2.1.157 | malfunction |
mutation or deletion of hadC affects the biosynthesis of oxygenated mycolic acids, substantially reducing their production level. Myxolic acid distribution is strongly affected by hadC mutation or deletion in Mtb H37Rv with a decrease in the methoxy-mycolic acid content compensated by an increase in alpha-mycolic acids. Additionally, it causes the loss of atypical extra-long mycolic acids. These events have an impact on the morphotype, cording capacity and biofilm growth of the bacilli as well as on their sensitivity to agents such as rifampicin. Deletion of hadC also leads to a dramatic loss of virulence: an almost 4-log drop of the bacterial load in the lungs and spleens of infected immunodeficient mice. Mycolic acids of Mycobacterium tuberculosis and impact of hadC mutation on their relative distribution, Effect of hadC mutation on the morphotype, biofilm growth, tolerance to stresses and virulence of Mycobacterium tuberculosis, phenotypes, detailed overview |
-, 748687 |
| 4.2.1.157 | malfunction |
mutation or deletion of hadC does not affect the growth of Mycobacterium tuberculosis. Myxolic acid distribution is strongly affected by hadC mutation or deletion in Mtb H37Ra with a decrease in the methoxy-mycolic acid content compensated by an increase in alpha-mycolic acids. Complementation of Mycobacterium tuberculosis strain H37Ra with either the wild-type hadC (hadCRv) or both wild-type hadB and hadC allele(s) (hadBCRv) from Mycobacterium tuberculosis strain H37Rv results in similar intermediate phenotypes. Effect of hadC mutation on the morphotype, biofilm growth, tolerance to stresses and virulence of Mycobacterium tuberculosis. Phenotypes, detailed overview |
-, 748687 |
| 4.2.1.157 | metabolism |
the enzyme is involved in L-leucine fermentation |
731782 |
| 4.2.1.157 | metabolism |
the enzyme is involved in the reductive branch of L-leucine fermentation |
731299 |
| 4.2.1.157 | physiological function |
involvement of HadBC in the late elongation steps of mycolic acid biosynthesis, involvement of hadC gene in the biosynthesis of atypical extra-long mycolic acids |
-, 748687 |
| 4.2.1.157 | physiological function |
involvement of HadBC in the late elongation steps of mycolic acid biosynthesis, involvement of hadC gene in the biosynthesis of atypical extra-long mycolic acids. Gene hadC is not essential for Mycobacterium tuberculosis growth, inactivity of the hadC gene of H37Ra. Mycolic acids are involved in the pathogenicity of mycobacteria suggesting that there might be a link between the mutation in hadC and the attenuation of Mtb H37Ra |
-, 748687 |
