Information on EC 4.2.1.157 - (R)-2-hydroxyisocaproyl-CoA dehydratase

for references in articles please use BRENDA:EC4.2.1.157
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase
IUBMB Comments
The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation. It catalyses an alpha/beta-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O
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