EC Number   |
General Information |
Reference |
|---|
    4.2.1.130 | evolution |
detailed phylogenetic analysis of GLOIII, DJ-1 and HSP31 proteins in fungi, overview |
729499 |
| 4.2.1.130 | evolution |
fungal Hsp31 proteins are the major glyoxalases III GLO3 that may have some role in protecting cells from reactive carbonyl species toxicity in fungi. The GLO3 activity of Hsp31 proteins may have evolved independently from GLO3 activity of DJ-1 proteins. DJ-1 and Hsp31 proteins belong to different subfamilies of the DJ-1/Hsp31/PfpI superfamily, which encompasses a wide variety of functionally diverse proteins, detailed phylogenetic analysis of DJ-1 and Hsp31 proteins, distribution of Hsp31 proteins in fungi, overview |
-, 729499 |
| 4.2.1.130 | evolution |
the enzyme belongs to the DJ-1 superfamily. DJ-1 superfamily proteins share the structural similarity, comprising central beta-strands surrounded by alpha-helices. Based on their primary sequences and 3D structures, the DJ-1 superfamily members are classified into three groups: DJ-1/YajL, YhbO/PfpI, and Hsp31/Ydr533C. The configuration of the active site of hDJ-1 is very different from that of Arabidopsis taliana atDJ-1d, apparently lacking some catalytic residues |
740433 |
| 4.2.1.130 | evolution |
the enzyme belongs to the DJ-1/PfpI superfamily. Unlike the homologues from other species, all the Arabidopsis thaliana genes have two tandem domains, which may have been created by gene duplication. The six AtDJ-1 proteins (a-f) are characterized |
-, 740429 |
| 4.2.1.130 | evolution |
the enzyme PfpI belongs to the PfpI/Hsp31/DJ-1 superfamily |
739999 |
| 4.2.1.130 | malfunction |
glyoxalase activity is completely abolished in the gene hchA-deficient strain. Stationary-phase Escherichia coli cells become more susceptible to methylgloxal when gene hchA is deleted, which can be complemented by an expression of plasmid-encoded hch. Accumulation of intracellular methylglyoxal in hchA-deficient strains |
716271 |
| 4.2.1.130 | malfunction |
the absence of the HSP31 gene sensitizes cells to oxidative, osmotic and thermal stresses, to potentially toxic products of glycolysis, such as methylglyoxal and acetic acid, and to the diauxic shift |
-, 752822 |
| 4.2.1.130 | malfunction |
the stationary-phase Escherichia coli cells becomes more susceptible to methylglyoxal when hchA is deleted |
716271 |
| 4.2.1.130 | metabolism |
overexpression of Hsp31 in tobacco imparts robust stress tolerance against diverse biotic stress inducers such as viruses, bacteria and fungi, in addition to tolerance against a range of abiotic stress inducers |
-, 755042 |
| 4.2.1.130 | more |
both DJ-1 and Hsp31 proteins possess the Glu-Cys-His catalytic triad, Glu16-Cys111-His130 in SpDJ-1 |
-, 729499 |
