EC Number   |
General Information |
Reference |
|---|
   3.6.1.B17 | evolution |
enzyme AtRH57 belongs to class II DEAD-box RNA helicase gene family. AtRH57 contains a DESD sequence in motif II and is thus classified into the DExD group |
-, 734916 |
| 3.6.1.B17 | malfunction |
Arabidopsis thaliana T-DNA insertion mutant rh57-1 exhibits hypersensitivity to glucose and abscisic acid. The other two rh57 mutants also show glucose hypersensitivity similar to rh57-1, strongly suggesting that the Glc-hypersensitive feature of these mutants results from mutation of AtRH57. Mutants rh57-1 and rh57-3 display severely impaired seedling growth when grown in Glc concentrations higher than 3%. Transcripts of Glc-responsive genes are altered in rh57 mutants, rh57 mutants exhibit abscisic acid hypersensitivity and enhanced abscisic acid accumulation by Glc. Decreased processing of pre-rRNA products in rh57 mutants. rh57-1 mutants show resistance to antibiotics, e.g. streptomycin. Phenotypes, overview |
-, 734916 |
| 3.6.1.B17 | malfunction |
when the enzyme helicase activity is impaired, enterovirus 71 RNA replication and virion production are mostly abolished in cells |
758192 |
| 3.6.1.B17 | metabolism |
AtRH57 acts in a signaling network downstream of hexokinase 1, HXK1 |
-, 734916 |
| 3.6.1.B17 | metabolism |
the enzyme is a spliceosomal DEAD-box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP-independent manner |
-, 755725 |
| 3.6.1.B17 | more |
the enzyme NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. Although the helicase domain, comprising amino acids 171 to 618, is an active enzyme, the protease domain has been proposed to have a modulatory role on the helicase and NTPase activities. RNA binding induces a conformational change in the NS3 to a closed form, while no changes in protein structure are observed in different nucleotide-bound states |
-, 735052 |
| 3.6.1.B17 | physiological function |
enzyme-mediated RNA remodeling plays a critical role in the enteroviral life cycle |
758192 |
| 3.6.1.B17 | physiological function |
the enzyme plays an important role in norovirus RNA replication |
757521 |
| 3.6.1.B17 | physiological function |
the participation of enzyme NS3, modulating the folding of cis-acting RNA elements by the dual RNA unwinding/annealing activities, provides an additional biological role for this viral protein |
-, 735052 |
