EC Number   |
General Information |
Reference |
|---|
    3.5.1.23 | evolution |
ADIPORs display distant homology with alkaline ceramidases, comparison of structures of ADIPOR1 and ADIPOR2 |
754889 |
| 3.5.1.23 | evolution |
ceramidases are classified into three distinct groups, acid (Asah1), neutral (Asah2), and alkaline (Asah3) CDases, based on their primary structure and optimum pH. Acid CDase catabolizes ceramide in lysosomes and is found only in vertebrates. In contrast, the distribution of neutral and alkaline CDases is broad, with both being found in species ranging from lower eukaryotes to mammals; however, only neutral CDase is found in prokaryotes, including some pathogenic bacteria. Neutral CDase is thought to have gained a specific domain (mucin box) in the N-terminal region after the vertebrate split, allowing the enzyme to be stably expressed at the plasmamembrane as a type II membrane protein. Molecular evolution of neutral ceramidase acquiring a mucin box, overview |
733408 |
| 3.5.1.23 | evolution |
distant homologues from nCDase are found in taxa all over evolution reinforcing a crucial role for ceramide |
752416 |
| 3.5.1.23 | evolution |
phylogenetic analysis of alkaline ceramidases |
734919 |
| 3.5.1.23 | evolution |
the Arabidopsis thaliana ceramidase AtNCER1 is a homologue of human neutral ceramidase |
-, 753711 |
| 3.5.1.23 | evolution |
the enzyme belongs to the CREST superfamily |
733290 |
| 3.5.1.23 | evolution |
the fold of ACER3 is similar to adiponectin receptors (ADIPORs), structure comparisons, overview |
754856 |
| 3.5.1.23 | malfunction |
a Dacer-deficient Drosophila melanogaster mutant has higher catalase (CAT) activity and CAT transcription level, leading to higher resistance to oxidative stress induced by paraquat. Altered antioxidative activity in Dacer mutant might be responsible for increased oxidative stress resistance. Quantitative proteomic analysis of wild-type and mutant cells. Three oxidoreductases, including two cytochrome P450 (CG3050, CG9438) and an oxoglutarate/iron-dependent dioxygenase (CG17807), are most significantly upregulated in the Dacer overexpressing mutant |
754351 |
| 3.5.1.23 | malfunction |
a significantly lower level of acid ceramidase expression was detected in gingival tissues from periodontal patients compared to those from healthy subjects |
752674 |
| 3.5.1.23 | malfunction |
a tetracycline-inducible ASAH1 short hairpin RNA H295R human adrenocortical stable cell line shows increased transcription of multiple steroidogenic genes, including Cytochrome P450 monooxygenase (CYP)17A1, CYP11B1/2, CYP21A2, steroidogenic acute regulatory protein, hormone-sensitive lipase, 18-kDa translocator protein, and the melanocortin-2 receptor. Induced gene expression positively correlates with enhanced histone H3 acetylation at target promoters. Repression of ASAH1 expression also induces the expression of members of the nuclear receptor nuclear receptor subfamily 4 family while concomitantly suppressing the expression of dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1. ASAH1 knockdown alters the expression of genes involved in sphingolipid metabolism and changes the cellular amounts of distinct sphingolipid species. Enzyme silencing increases basal and cAMP-dependent cortisol and dehydroepiandrosterone secretion, establishing ASAH1 as a pivotal regulator of steroidogenic capacity in the human adrenal cortex |
720471 |
