EC Number   |
General Information |
Reference |
|---|
   3.2.1.166 | evolution |
the enzyme belongs to the clan A glycoside hydrolase family 79, GH79 |
731254 |
| 3.2.1.166 | evolution |
the enzyme belongs to the glycoside hydrolase family 79, GH79 |
731648, 731884 |
| 3.2.1.166 | evolution |
the enzyme belongs to the glycoxadside hydrolase family 79, GH79 |
754873 |
| 3.2.1.166 | evolution |
the enzyme belongs to the glycoxadside hydrolase family 79, GH79, from GH clan A |
754818 |
| 3.2.1.166 | malfunction |
enhanced growth/aggressiveness of numerous cancer cell types following overexpression of heparanase and inhibition of the tumorigenic/metastatic abilities of cancer cells following heparanase gene silencing |
732436 |
| 3.2.1.166 | malfunction |
enzymatically inactive heparanase: mutated heparanase designated M343 fails to stimulate exosome secretion, whereas mutant M225 has a mild stimulatory effect |
732087 |
| 3.2.1.166 | malfunction |
enzyme inhibition decreases the release of IL-1beta and TNF-alpha significantly, but does not change the mRNA levels of IL-1beta and TNF-alpha significantly in Astragalus membranaceus extract-treated macrophages |
732546 |
| 3.2.1.166 | malfunction |
heparanase knockdown impairs neurite outgrowth induced by nerve growth factor |
714108 |
| 3.2.1.166 | malfunction |
heparanase variant T5 overexpression results in increased cell proliferation and larger colonies in soft agar, mediated by Src activation |
714936 |
| 3.2.1.166 | malfunction |
in siRNA treated T-cells, the repressing H3K9ac activation mark is reduced, with transcriptional repression of the CD69, IFNalpha and IL-2 genes and a concomitant decrease in H3K4me1 levels, accumulation of H3K4m2, not H3K4m3 |
732954 |
