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3.1.1.90
evolution
it is likely that the two novel homologues of RPE65 (13cIMH and RPE65c,
EC 3.1.1.90
and
EC 3.1.1.64
, respectively) are generated through gene duplication after the separation of fish RPE65 from the ancestral RPE65, because they exhibit an extremely high level of sequence identity (97%) and are located in the same chromosome, but on a different chromosome from RPE65
729213
3.1.1.90
more
key residues determining the isomerization product specificity of the enzyme are Tyr58, Phe103, and Leu133
729213
3.1.1.90
physiological function
the enzyme plays a key role in the generation of 13-cis retinoic acid, as well as in the modulation of neuronal functions in the brain
714991
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