EC Number   |
General Information |
Reference |
|---|
  2.7.7.99 | metabolism |
the enzyme is involved in peptidoglycan cell wall biosynthesis |
-, 761351 |
| 2.7.7.99 | metabolism |
the two major cell wall recycling enzymes are AmgK and MurU. This specific cell wall recycling machinery, present in many bacterial species including Pseudomonas putida, includes the recycling enzyme AmgK that converts NAM into MurNAc 1-phosphate, which is then converted to UDP-MurNAc (UDP-NAM) by MurU. These enzymes produce UDP-NAM, a critical precursor involved in the initial steps of the bacterial cell wall biosynthesis. Peptidoglycan biosynthetic and recycling pathway, overview |
-, 761819 |
| 2.7.7.99 | physiological function |
enzyme is involved in a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid. The pathway consisits of anomeric sugar kinase AmgK and the MurNAc alpha-1-phosphate uridylyl transferase MurU. Deletion of the encoding gene increases fosfomycin sensitivity |
-, 743335 |
| 2.7.7.99 | physiological function |
the metabolic pathway of anomeric cell wall amino sugar kinase AmgK and uridylyl transferase MurU converts N-acetylmuramic acid to uridine diphosphate-N-acetylmuramic acid. It is responsible for the high intrinsic resistance of Pseudomonas aeruginosa to fosfomycin due to bypassing the fosfomycin-sensitive de novo synthesis of UDP-N-acetylmuramic acid |
-, 743237 |
