Information on EC 2.7.7.99 - N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase

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The expected taxonomic range for this enzyme is: Pseudomonas putida

EC NUMBER
COMMENTARY hide
2.7.7.99
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RECOMMENDED NAME
GeneOntology No.
N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + phosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
anhydromuropeptides recycling II
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Amino sugar and nucleotide sugar metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
UDP:N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UTP + N-acetyl-alpha-D-muramate 1-phosphate
UDP-N-acetyl-alpha-D-muramate + diphosphate
show the reaction diagram
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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two Mg2+ ions are likely part of the active site. Mg2+ is not required for substrate binding per se
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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1 mM, complete loss of activity
PDB
SCOP
CATH
UNIPROT
ORGANISM
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440);
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000 - 27000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystal structures of MurU in native and ligand-bound states at 1.8 A resolution
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