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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.7.4.29physiological function a chromosomal deletion mutant cannot phosphorylate lipid A 732533
Display the reaction diagram Show all sequences 2.7.4.29physiological function effect of LpxT ectopic expression from a plasmid in Escherichia coli. LpxT induction inhibits cell division and leads to the formation of elongated cells, mostly with absent or altered septa. The cells become sensitive to detergents and to hypoosmotic shock. LpxT overexpression in mutants lacking the L,D-transpeptidase LdtD and LdtE causes cell envelope defects. Diphosphorylated lipid A is also produced in a LpxT deletion mutant 761861
Display the reaction diagram Show all sequences 2.7.4.29physiological function enzyme is able to complement an Escherichia coli LpxT mutant. In Pseudomonas aeruginosa, an LpxT deletion mutant cannot phosphorylate lipid A -, 761930
Display the reaction diagram Show all sequences 2.7.4.29physiological function enzyme LpxT-catalysed phosphorylation is dependent upon transport of lipid A across the inner membrane by MsbA, a lipid A flippase 732529
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