Literature summary for 2.7.4.29 extracted from

Nowicki, E.M.; OBrien, J.P.; Brodbelt, J.S.; Trent, M.S.
Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and co-ordinated control of outer membrane modification (2014), Mol. Microbiol., 94, 728-741.

Search for more literature for 2.7.4.29

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	modulation of LpxTPa activity is influenced by transcription of the lipid A aminoarabinose transferase ArnT	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
Mg2+	limiting Mg2+ during growth results in inhibition of enzyme LpxT activity. Modulation is independent of transcription	Pseudomonas aeruginosa
additional information	modulation of LpxTPa activity is influenced by transcription of the lipid A aminoarabinose transferase ArnT	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	Pseudomonas aeruginosa	ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate	phosphate modification of lipid A can occur both at the 1-phosphate and the 4'-phosphate groups	?
ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A	-	Pseudomonas aeruginosa	ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 4'-diphosphate	phosphate modification of lipid A can occur both at the 1-phosphate and the 4'-phosphate groups	?

Synonyms

Synonyms	Comment	Organism
LptX	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
physiological function	a chromosomal deletion mutant cannot phosphorylate lipid A	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)