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2.3.1.301
metabolism
ordering or closing of the FabH on the substrate or inhibitor is required for efficient reaction with the active site cysteine. The acyl-CoA reactant, in principle, could synchronously bind to both arms of the exposed substrate binding site. Movement to the closed form, and reaction with Cys112, would follow. CoA product released from the mouth of the pantetheinate channel would then complete the first stage of the reaction
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760859
2.3.1.301
metabolism
reaction occurs at both subunits and shows strict specificity for dodecyl-CoA
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760679
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