Information on EC 2.3.1.301 - mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III

for references in articles please use BRENDA:EC2.3.1.301
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EC Tree
IUBMB Comments
The enzyme, characterized from mycobacteria, provides a link between the type I and type II fatty acid synthase systems (FAS-I and FAS-II, respectively) found in these organisms. The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16) produced by the FAS-I system, condensing them with malonyl-[acyl-carrier protein] (malonyl-AcpM) and forming starter molecules for the FAS-II system, which elongates them into meromycolic acids. The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-CoA), which are used by EC 2.3.1.180, beta-ketoacyl-[acyl-carrier-protein] synthase III, or branched-chain acyl-CoAs, which are used by EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.
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The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Reaction Schemes
Synonyms
FabH, mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III, Rv0533c, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dodecanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxotetradecanoyl-[acyl-carrier protein] + CoA + CO2
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PATHWAY SOURCE
PATHWAYS
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