EC Number   |
General Information |
Reference |
|---|
   2.3.1.206 | metabolism |
the enzyme is involved in the biosynthesis of cannabinoids, the glandular trichomes from female cannabis flowers are the primary site of cannabinoid biosynthesis, proposed cannabinoid biosynthetic pathway, overview. TKS synthesizes a diffusible intermediate that is converted to olivetolic acid by OAC |
720934 |
| 2.3.1.206 | metabolism |
the enzyme is involved the biosynthesis of the first precursor of cannabinoids, olivetolic acid. Cannabinoid and flavonoid profiling, overview. Accumulation of cannabinoids in bracts during the growth and development of glandular trichomes from flowers, cannabinoid accumulation iscorrelated with maximum activities for an olivetol-forming PKS, developmental and defens-related regulation of cannabinoid pathway enzymes, overview |
706171 |
| 2.3.1.206 | metabolism |
the polyketide synthase catalyzes the first step of cannabinoid biosynthesis, leading to olivetolic acid |
720760 |
| 2.3.1.206 | more |
factors might affect the timing of the hydrolysis and cyclization reactions by olivetol synthase to form an olivetolic acid-forming metabolic complex together with olivetol synthase, metabolon formation |
719492 |
| 2.3.1.206 | physiological function |
olivetolic acid is the first intermediate involved in the cannabinoid biosynthesis in Cannabis sativa leading to the acidic forms of the major cannabinoids such as DELTA9-tetrahydrocannabinolic acid and cannabinolic acid |
720760 |
| 2.3.1.206 | physiological function |
polyketide synthases play an important role in the biosynthesis of secondary metabolites such as resveratrol, a candidate for cancer chemoprevention and naringenin, the precursor for flavonoids. Olivetolic acid is also be expected to be synthesized by a PKS |
-, 720721 |
| 2.3.1.206 | physiological function |
the type III PKS, i.e. tetraketide synthase, from cannabis trichomes requires the presence of a polyketide cyclase enzyme, olivetolic acid cyclase, which catalyzes a C2-C7 intramolecular aldol condensation with carboxylate retention to form olivetolic acid. No physical interaction of TKS and OAC. Polyketide cyclases may play a role in generating plant chemical diversity |
720934 |
