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1.8.1.14
malfunction
spirochetes lacking CoADR exhibit a growth defect under both aerobic and anaerobic conditions. Enzyme loss affects survival of spirochete in fed, but not flat tick nymphs
-
,
726003
1.8.1.14
physiological function
the enzyme is not essential for S0 respiration in Pyrococcus but appears to participate in oxidative defense in the presence of elemental sulfur
724377
1.8.1.14
physiological function
the enzyme of Borrelia burgdorferi is necessary to maintain optimal redox ratios for CoA/CoA-disulfide and NAD+/NADH during periods of rapid replication throughout the enzootic cycle, to support thiol-disulfide homeostasis, and to indirectly protect the spirochete against peroxide-mediated membrane damage. The enzyme is also required for infectivity in mice
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726003
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