EC Number   |
General Information |
Reference |
|---|
   1.2.1.36 | malfunction |
ablation of retinoic acid signaling in host dencritic cells by deletion of isoform RALDH2 protects mice from acute graft-versus-host disease. Isoform RALDH1 deletion fails to reduce acute graft-versus-host disease |
763337 |
| 1.2.1.36 | malfunction |
acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages |
743375 |
| 1.2.1.36 | evolution |
aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the aldehyde dehydrogenase superfamily that oxidizes aldehydes to their corresponding acids, reactions that are coupled to the reduction of NAD+ to NADH |
763529 |
| 1.2.1.36 | physiological function |
aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD+ reduction. ALDH1A1 can also use glutathione (GSH) and dihydrolipoic acid (DHLA) as electron donors to reduce NAD+ to NADH. The GSH/DHLA-dependent NAD+-reduction activity of ALDH1A1 is not affected by the aldehyde dehydrogenase inhibitor or by mutation of the residues in its aldehyde-binding pocket. It is thus a distinct biochemical reaction from the classic aldehyde-dehydrogenase activity catalyzed by ALDH1A1. The GSH/DHLA-dependent NAD+-reduction activity of ALDH1A1 can decrease cellular NAD(P)+/NAD(P)H ratio and promote tumor growth. The tumor-promoting effect of ALDH1A1 is achieved, at least partially, through decreasing the cellular NAD+/ NADH ratio |
763529 |
| 1.2.1.36 | metabolism |
ALDH1A1 and ALDH3A1 have the same GSH/DHLA-dependent NAD+-reduction activity |
763529 |
| 1.2.1.36 | physiological function |
ALDH1A1 contributes to protection of A-549 cells against retinaldehyde toxicity. ALDH1 confers protection against retinaldehyde toxicity in cancer cells |
763530 |
| 1.2.1.36 | physiological function |
ALDH1A1 is a NAD+-dependent aldehyde dehydrogenase that participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes |
762790 |
| 1.2.1.36 | metabolism |
both isoforms Raldh1 and -2 contribute to atRA biosynthesis in hippocampus astrocytes |
725461 |
| 1.2.1.36 | physiological function |
changes in ALDH1A1 expression appear to be part of the early acute-phase inflammatory response, which alters the expression of other retinoid homeostatic genes |
743375 |
| 1.2.1.36 | physiological function |
enzyme BcALDH is an atypical aldehyde dehydrogenase having bidirectional oxidizing and reducing activities |
763136 |
