EC Number   |
General Information |
Reference |
|---|
   1.14.99.66 | evolution |
histone methylation can be reversed by several histone demethylases, including PAD4/PADI4, BHC110/LSD1, and JmjC domain-containing demethylases. a family of multiprotein complexes contains histone deacetylase 1/2 (HDAC1/2) and the histone demethylase LSD1 (BHC110). LSD1 demethylates mono- and dimethyl histone H3 lysine 4 (H3K4) and belongs to a family of FAD-dependent polyamine oxidases which use molecular oxygen as an electron acceptor to oxidize an amine group |
754723 |
| 1.14.99.66 | evolution |
LSD1 belongs to the amine oxidase family which are flavin-dependent enzymes that utilize O2 and generate H2O2 and formaldehyde as byproducts |
753965 |
| 1.14.99.66 | evolution |
LSD1 belongs to the flavin adenine dinucleotide (FAD)-dependent amino oxidase family and is conserved in Schizosaccharomyces pombe through humans |
752795 |
| 1.14.99.66 | evolution |
the enzyme belongs to the JARID family. JARID proteins contain, in addition to the JmjN and JmjC domains, ARID and C5HC2-zinc finger domains, which mediate DNA binding. JARID proteins are, in turn, divided into two subgroups according to the presence, JARID1, or not, JARID2, of chromatin-binding PHD domains |
754921 |
| 1.14.99.66 | malfunction |
a KDM1 mutant is embryonic lethal, analysis of demethylase developmental expression patterns and mutant/knockdown phenotypes, overview |
-, 753349 |
| 1.14.99.66 | malfunction |
a KDM1 mutant T08D10.2 shows extended lifespan, analysis of demethylase developmental expression patterns and mutant/knockdown phenotypes, overview |
753349 |
| 1.14.99.66 | malfunction |
a strong increase in H3K4me3 is detected in polytene chromosomes from homozygous lid12367 mutants. Gene lid mutations result in small imaginal discs |
754921 |
| 1.14.99.66 | malfunction |
Cre-induced deletion of SALL4 in gene-targeted BM progenitors results in a remarkable decrease of SALL4-bound and LSD1-bound EBF1, accompanied by a 750fold increase of Lys4-dimethylated histon H3. Knockdown of LSD1 in bone marrow hematopoietic stem and progenitor cells leads to altered SALL4 downstream gene expression and increased cellular activity |
-, 725541 |
| 1.14.99.66 | malfunction |
depletion of LSD1 in an immortalized olfactory-placode-derived cell line (OP6) results in multigenic and multiallelic odorant receptor (OR) transcription per cell, while not seemingly disrupting the ability of these cells to activate new OR genes during clonal expansion. LSD1 depletion does not seem to alter OR representation in OP6 cell populations. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations |
745771 |
| 1.14.99.66 | malfunction |
depletion of LSD1 or inhibition of its activity with monoamine oxidase inhibitors (MAOIs) results in the accumulation of repressive chromatin and a block to viral gene expression. HCF-1 depletion resulted in a concomitant decrease in the recruitment of LSD1 |
754857 |
