EC Number   |
General Information |
Reference |
|---|
    1.1.1.34 | evolution |
not only the sequence of the catalytic domain of enzyme HMGR but also its quaternary structure is conserved in high eukaryotes. HMGR is encoded by a multigene family |
740956 |
| 1.1.1.34 | malfunction |
inhibition of enzyme expression promotes the accumulation of anthocyanins and fruit coloration |
761343 |
| 1.1.1.34 | malfunction |
the enzyme is important in the biosynthesis of terpenoids such as patchouli alcohol |
762318 |
| 1.1.1.34 | metabolism |
3-hydroxy-3-methylglutaryl Co-A reductase is a rate-limiting enzyme in the eukaryotic mevalonate pathway |
-, 723598 |
| 1.1.1.34 | metabolism |
3-hydroxy-3-methylglutaryl CoA reductase catalyzes the first committed step in the mevalonic acid (MVA) pathway for the biosynthesis of isoprenoids |
722329 |
| 1.1.1.34 | metabolism |
enzyme overexpression significantly increases abscisic acid, gibberellic acid, carotene, and lycopene content, indicating that the enzyme participates in the regulation of terpenoid compound synthesis |
761172 |
| 1.1.1.34 | metabolism |
HMG-CoA reductase (HMGR) catalyzes the first committed step of the mevalonate pathway for isoprenoid biosynthesis, consisting in the NADPH-mediated reductive deacylation of HMG-CoA to mevalonic acid. The enzyme exerts a key regulatory role on the flux of the mevalonate pathway in all eukaryotes |
740956 |
| 1.1.1.34 | metabolism |
HMG-CoA reductase is the rate-limiting enzyme of cholesterol biosynthesis |
712189 |
| 1.1.1.34 | metabolism |
HMGR catalyzes the first committed step in mevalonic acid pathway for biosynthesis of isoprenoids |
710786 |
| 1.1.1.34 | metabolism |
HMGR catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols. Mevalonate is a precursor of isoprenoids, a class of compounds involved in several cellular functions such as cholesterol synthesis and growth control |
712214 |
