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Literature summary for 1.1.1.34 extracted from

  • Lin, J.; Jin, Y.; Zhou, M.; Zhou, X.; Wang, J.
    Molecular cloning, characterization and functional analysis of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Jatropha curcas (2009), Afr. J. Biotechnol., 8, 3455-3462.
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Cloned(Commentary)

Cloned (Comment) Organism
gene hmgr, genomic DNA sequence and full-length cDNA, as well as JcHMGR amino acid sequence determination and analysis, phylogenetic analysis, expression in Escherichia coli strain Top 10F' Jatropha curcas

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62400
-
 x * 62400, about, sequence calculation Jatropha curcas

Organism

Organism UniProt Comment Textmining
Jatropha curcas
-
 collected from Panzhihua, Sichuan province, China, gene hmgr
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Jatropha curcas
-

Subunits

Subunits Comment Organism
? x * 62400, about, sequence calculation Jatropha curcas
More JcHMGR has three domains: 1. the small, helical N-terminal N-domain, 2. the large, central L-domain harboring two HMG-CoA binding motifs EMPIGFLQIP and TTEGCLVA, and an NADP(H)-binding motif GTVGGGT, and 3. the small helical S-domain harboring an NADP(H)-binding motif characterized by the sequence DAMGMN Jatropha curcas

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl coenzyme A reductase
-
 Jatropha curcas
HMGR
-
 Jatropha curcas

pI Value

Organism Comment pI Value Maximum pI Value
Jatropha curcas sequence calculation
-
 7.63

General Information

General Information Comment Organism
metabolism HMGR catalyzes the first committed step in mevalonic acid pathway for biosynthesis of isoprenoids Jatropha curcas