EC Number   |
General Information |
Reference |
|---|
   2.4.1.228 | physiological function |
globotriaosylceramide, Gb3, synthesized from lactosylceramide by alpha1,4-galactosyltransferase Gb3/CD77 synthase, is a well known receptor for Shiga toxin, Stx, produced by enterohemorrhagic Escherichia coli and Shigella dysenteriae |
722691 |
| 2.4.1.228 | physiological function |
the A4GALT gene encodes the alpha1-4 galactosyltransferase, a key enzyme responsible for synthesis of globoside glycosphingolipids. Globo series-related genes, and in particular, A4GALT, are elevated in epithelial cancer cells and associated with improved patient's outcome |
758994 |
| 2.4.1.228 | physiological function |
the enzyme catalyzes the synthesis of Gal(alpha1-4)Gal moiety in globotriaosylceramide (Gb3Cer, CD77, Pk blood group antigen), a glycosphingolipid of the globo series |
735618 |
| 2.4.1.228 | physiological function |
the enzyme is involved in the biosynthesis of unique globoside (Gb4Cer) derivatives, NOR1, NORint, and NOR2, in which Gal(alpha1-4), GalNAc(beta1-3)Gal(alpha1-4), and Gal(alpha1-4)GalNAc(beta1-3)Gal(alpha1-4), respectively, are linked to the terminal GalNAc residue of Gb4Cer, transfer of Gal to GalNAc, overview |
722791 |
