EC Number |
General Information |
Reference |
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1.2.1.24 | more |
human SSADH intrinsic regulatory mechanism, redox-switch modulation, by which large conformational changes are brought about in the catalytic loop through disulfide bonding, enzyme molecular structure, overview |
743762 |
1.2.1.24 | physiological function |
enzyme SSADH is a NAD+-dependent mitochondrial homotetrameric allosteric enzyme and works with gamma-aminobutyric acid (GABA) transaminase to convert GABA to succinic semialdehyde (SSA) which is, in turn, oxidized by SSADH to succinic acid. Besides its established role in GABA catabolism, SSADH is reported to contribute to the antioxidative mitochondrial defence by oxidation of 4-hydroxynonenal, a degradation end product of peroxidated lipids |
763472 |
1.2.1.24 | physiological function |
GABA can feed the TCA cycle via the activities of GABA transaminase and succinic semialdehyde dehydrogenase (SSADH) to produce succinate. Potential role of GABA shunt and SSADH activity in the survival and the proliferation of SSADH expressing U-251 wild-type cells |
763330 |