EC Number   |
Expression |
Reference |
|---|
   3.6.5.2 | down |
8CPT-2Me-cAMP suppresses GTP-RhoA levels |
-, 734361 |
| 3.6.5.2 | down |
hRAB37 is downregulated mainly by promoter hypermethylation in lung cancer cells |
734751 |
| 3.6.5.2 | down |
si-RNAs of Epac1 and Epac2 reduced GTP-Rap1 levels |
-, 734361 |
| 3.6.5.2 | more |
expression levels of Rap2a in macrophages might be tightly regulated to avoid unbalanced immune response |
757678 |
| 3.6.5.2 | more |
knockdown of Rab isoform Rab2A induces fragmentation of the Golgi in HeLa-S3 cells, its phenotype is rescued by re-expression of its siRNA-resistant Rab construct alone, not by any of the other five Rab isozymes |
734312 |
| 3.6.5.2 | more |
overexpression of any type of Rhebs (wild-type, constitutively active form, and dominant-negative form) does not affect the intact microtubule structure, and the vesicle-formed Rheb does not co-localize with the microtubule network |
733638 |
| 3.6.5.2 | up |
putative activator TLR-inducible Ras guanine exchange factor RasGEF1b is sufficient to induce, it is not fully required for Rap2a activation. In contrast to mRNA levels, Rap2a protein levels are increased after lipopolysaccharide treatments of macrophages |
757678 |
| 3.6.5.2 | up |
Rab13 is the most significantly upregulated gene in pterostilbene-treated human umbilical VECs (HUVECs) |
756101 |
| 3.6.5.2 | up |
RhoB is the only member of the Rho subfamily of small GTPases, which is classified as an immediate early gene product. RhoB is up-regulated in response to growth factors as well as cytotoxic and genotoxic agents. Clostridial glucosylating toxins evoke pronounced RhoB expression, based on the inactivation of Rho/Ras proteins. Long lasting expression of RhoB in cultured cells upon activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli. Deamidase-deficient CNF1-C866S fails to activate the rhoB promoter, CNF1-C866S only faintly induces expression of rhoB mRNA and RhoB protein. Critical role of Rac1 in CNF1-induced RhoB expression, overview |
733982 |
| 3.6.5.2 | up |
RhoB is the only member of the Rho subfamily of small GTPases, which is classified as an immediateearly gene product. RhoB is up-regulated in response to growth factors as well as cytotoxic and geno-toxic agents. Clostridial glucosylating toxins evoke pronounced RhoB expression, based on the inactivation of Rho/Ras proteins. Long lasting expression of RhoB in cultured cells upon activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli. CNF1-induced RhoB expression in primary and immortalized NIH3T3 fibroblasts. Deamidase-deficient CNF1-C866S fails to activate the rhoB promoter, CNF1-C866S only faintly induces expression of rhoB mRNA and RhoB protein. Critical role of Rac1 in CNF1-induced RhoB expression, overview |
733982 |
