EC Number   |
Expression |
Reference |
|---|
   3.4.24.23 | down |
1,25-dihydroxyvitamin D3, i.e. 1, 25(OH)2D3, significantly reduces the MMP-7 and MMP-9 and increases the TIMP-1 inhibitor level in Mycobacterium tuberculosis antigen stimulated and unstimulated mononuclear cell cultures of pulmonary tunerculosis patients as compared to healthy persons |
708198 |
| 3.4.24.23 | down |
andrographolide diminishes the activity and the mRNA and protein levels of MMP-7, but not MMP-2 or MMP-9. The downregulation of MMP-7 appears to be via the inactivation of activator protein-1, AP-1, overview |
708084 |
| 3.4.24.23 | down |
dominant negative insulin-like growth factor-I receptor, i.e. IGF-IR/dn, suppresses MMP-7 expression in invasive subcutaneous tumors. IGF-stimulated secretion of matrilysin and IGF-IR/dn blocks IGF-mediated matrilysin induction in three gastrointestinal cancers, overview |
708011 |
| 3.4.24.23 | down |
expression of MMP-7 is downregulated by tamoxifen and 5-fluorouracil in combination in HT-29 cells |
709318 |
| 3.4.24.23 | down |
fibulin-5 downregulates MMP-7, suppression of fibulin-5, as well as deletion of its RGD motif, induces MMP-7 expression in lung. Suppression of MMP-7 expression by fibulin-5 is mediated by an integrin-binding RGD motif via the extracellular signal-regulated kinase pathway |
707986 |
| 3.4.24.23 | down |
inhibition of hyaluronan synthases HAS2 and HAS3 highly decreases MMP-7 expression and activity in SW620 cells |
706795 |
| 3.4.24.23 | down |
resveratrol inhibits MMP7 expression |
753505 |
| 3.4.24.23 | down |
TIMP-1 from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity. TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites |
709561 |
| 3.4.24.23 | down |
yes-associated protein (YAP) knockdown decreases MMP-7 expression. Treatment with inhibitors of epidermal growth factor receptor (EGFR) and myosin regulatory light chain (MRLC) and integrin-alpha2 or integrin-beta1 knockdown downregulate MMP-7 expression |
754942 |
| 3.4.24.23 | more |
no apparent regulation of the expression of MMP-7 by either tumor necrosis factor or enamel matrix derivative |
709669 |
